HTLV1 Target gene Detail Information

> PRKCI Gene Search Result

Gene Information

Gene Name	PRKCI
Gene ID	5584
Gene Full Name	protein kinase C iota
Gene Alias	PKCI; DXS1179E; nPKC-iota
Transcripts	ENSG00000163558
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Cytokinetic bridge;Microtubules;
HPA Protein Class Info	Cancer-related genes, Enzymes, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P41743
HGNC ID	HGNC:9404
VEGA ID	OTTHUMG00000150214
OMIM ID	600539
String ID	9606.ENSP00000295797
Drugbank ID	BE0003889; BE0004895
PharmGKB ID	PA33768

Target gene [PRKCI] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002508	chr3	86	130	20	236	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PRKCI expression and immune infiltrating cell level correlation result in HTLV1+ samples
PRKCI expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PRKCI expression and immune infiltrating cell level correlation result in HTLV1+ samples
PRKCI expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PRKCI expression and immune infiltrating cell level correlation result in HTLV1+ samples
PRKCI expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).