HBV Target gene Detail Information

> PRKCA Gene Search Result

Gene Information

Gene Name	PRKCA
Gene ID	5578
Gene Full Name	protein kinase C alpha
Gene Alias	AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha
Transcripts	ENSG00000154229
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Oncogene
Uniport_ID	P17252
HGNC ID	HGNC:9393
VEGA ID	OTTHUMG00000179533
OMIM ID	176960
String ID	9606.ENSP00000408695
Drugbank ID	BE0001132; BE0004895
PharmGKB ID	PA33759

Target gene [PRKCA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1012198	chr17	5	2		7	View
1400027	chr17	11	21	76	108	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PRKCA expression and immune infiltrating cell level correlation result in HBV+ samples
PRKCA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).