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EBV Target gene Detail Information

> PRKAA2 Gene Search Result


Gene Information
Gene Name PRKAA2
Gene ID 5563
Gene Full Name protein kinase AMP-activated catalytic subunit alpha 2
Gene Alias AMPK; AMPK2; PRKAA; AMPKa2
Transcripts ENSG00000162409
Virus EBV
Gene Type protein coding
HPA Location Info Nuclear speckles;Golgi apparatus;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Predicted membrane proteins, Transporters
Gene Function Suppressor gene
Uniport_ID P54646
HGNC ID HGNC:9377
VEGA ID OTTHUMG00000008282
OMIM ID 600497
String ID 9606.ENSP00000360290
Drugbank ID BE0004843; BE0004907
Drug (Cytoscape Annotation) Sunitinib Malate
PharmGKB ID PA33745
Target gene [PRKAA2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
3000630 chr1 8 8 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE102203 (GEO) B-cell lymphoma 9 Plasmablastic lymphomas (EBV+)(6), Plasmablastic lymphomas (EBV-)(3)
GSE100458 (GEO) Burkitt lymphoma 14 Burkitt lyphoma cell line Akata(EBV+)(2),Burkitt lyphoma cell line Akata(EBV-)(2),Burkitt lyphoma cell line Awia(EBV+)(2),Burkitt lyphoma cell line Awia(EBV-)(2),Burkitt lyphoma cell line Eli(EBV+)(1),Burkitt lyphoma cell line Eli(EBV-)(1),Burkitt lyphoma cell line Mutu(EBV+)(2),Burkitt lyphoma cell line Mutu(EBV-)(2)
GSE42867 (GEO) Burkitt lymphoma 12 Burkitt lymphoma cell line Awia (EBV+)(12)
GSE135644 (GEO) Gastric carcinoma 10 Gastric adenocarcinoma cell line AGS (5), Gastric adenocarcinoma cell line AGS (EBV+)(5)
GSE45919 (GEO) Infectious mononucleosis 24 Infectious mononucleosis (IM)(EBV+)(3), Normal (9), Latent EBV (12)
GSE85599 (GEO) Infectious mononucleosis 17 Chronic active EBV infection (EBV+)(5), Acute infectious mononucleosis (EBV+)(6), Normal (6)
GSE58240 (GEO) Multiple sclerosis 32 Multiple sclerosis IFN-β treated (EBV+)(16), Multiple sclerosis untreated (EBV+)(16)
GSE12452 (GEO) Nasopharyngeal carcinoma 41 Nasopharyngeal carcinoma (EBV+)(31), Normal(10)

> Dataset: GSE102203

HeatMap of cell type fractions in all samples Lollipop of PRKAA2 expression and immune infiltrating cell level correlation result in EBV+ samples
PRKAA2 expression: Low -> High

> Dataset: GSE100458

HeatMap of cell type fractions in all samples Lollipop of PRKAA2 expression and immune infiltrating cell level correlation result in EBV+ samples
PRKAA2 expression: Low -> High

> Dataset: GSE42867

HeatMap of cell type fractions in all samples Lollipop of PRKAA2 expression and immune infiltrating cell level correlation result in EBV+ samples
PRKAA2 expression: Low -> High

> Dataset: GSE135644

HeatMap of cell type fractions in all samples Lollipop of PRKAA2 expression and immune infiltrating cell level correlation result in EBV+ samples
PRKAA2 expression: Low -> High

> Dataset: GSE45919

HeatMap of cell type fractions in all samples Lollipop of PRKAA2 expression and immune infiltrating cell level correlation result in EBV+ samples
PRKAA2 expression: Low -> High

> Dataset: GSE85599

HeatMap of cell type fractions in all samples Lollipop of PRKAA2 expression and immune infiltrating cell level correlation result in EBV+ samples
PRKAA2 expression: Low -> High

> Dataset: GSE58240

HeatMap of cell type fractions in all samples Lollipop of PRKAA2 expression and immune infiltrating cell level correlation result in EBV+ samples
PRKAA2 expression: Low -> High

> Dataset: GSE12452

HeatMap of cell type fractions in all samples Lollipop of PRKAA2 expression and immune infiltrating cell level correlation result in EBV+ samples
PRKAA2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).