HIV Target gene Detail Information

> PRKAA1 Gene Search Result

Gene Information

Gene Name	PRKAA1
Gene ID	5562
Gene Full Name	protein kinase AMP-activated catalytic subunit alpha 1
Gene Alias	AMPK; AMPKa1
Transcripts	ENSG00000132356
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;Cytosol;
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q13131
HGNC ID	HGNC:9376
VEGA ID	OTTHUMG00000162269
OMIM ID	602739
String ID	9606.ENSP00000346148
Drugbank ID	BE0000677; BE0004907
PharmGKB ID	PA33744

Target gene [PRKAA1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4012498	chr5	5			5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PRKAA1 expression and immune infiltrating cell level correlation result in HIV+ samples
PRKAA1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PRKAA1 expression and immune infiltrating cell level correlation result in HIV+ samples
PRKAA1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).