HTLV1 Target gene Detail Information

> PRICKLE2 Gene Search Result

Gene Information

Gene Name	PRICKLE2
Gene ID	166336
Gene Full Name	prickle planar cell polarity protein 2
Gene Alias	EPM5
Transcripts	ENSG00000163637
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Vesicles;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q7Z3G6
HGNC ID	HGNC:20340
VEGA ID	OTTHUMG00000158789
OMIM ID	608501
String ID	9606.ENSP00000295902
PharmGKB ID	PA134883144

Target gene [PRICKLE2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004252	chr3	115	8		123	View
6007097	chr3	15	28	16	59	View
6013120	chr3	6	14		20	View
6018343	chr3	6	3		9	View
6020649	chr3	4	1	1	6	View
6023396	chr3	2	2		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PRICKLE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PRICKLE2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PRICKLE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PRICKLE2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PRICKLE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PRICKLE2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).