HBV Target gene Detail Information

> PREX2 Gene Search Result

Gene Information

Gene Name	PREX2
Gene ID	80243
Gene Full Name	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
Gene Alias	DEP.2; DEPDC2; P-REX2; PPP1R129
Transcripts	ENSG00000046889
Virus	HBV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q70Z35
HGNC ID	HGNC:22950
VEGA ID	OTTHUMG00000164402
OMIM ID	612139
String ID	9606.ENSP00000288368
PharmGKB ID	PA164725103

Target gene [PREX2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1003846	chr8	38	58	14	110	View
1006354	chr8	10	29		39	View
1008913	chr8	14	3	1	18	View
1401755	chr8	14	3	1	18	View
1403715	chr8	10	29		39	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PREX2 expression and immune infiltrating cell level correlation result in HBV+ samples
PREX2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).