HIV Target gene Detail Information

> PPP6R3 Gene Search Result

Gene Information

Gene Name	PPP6R3
Gene ID	55291
Gene Full Name	protein phosphatase 6 regulatory subunit 3
Gene Alias	SAPL; PP6R3; SAPLa; SAPS3; SAP190; C11orf23
Transcripts	ENSG00000110075
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q5H9R7
HGNC ID	HGNC:1173
VEGA ID	OTTHUMG00000167596
OMIM ID	610879
String ID	9606.ENSP00000377390
PharmGKB ID	PA25487

Target gene [PPP6R3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003257	chr11	4	60	1	65	View
4003505	chr11	27	32	1	60	View
4004600	chr11	25	17		42	View
4005050	chr11	9	17	10	36	View
4006866	chr11	21		1	22	View
4007990	chr11	15	2		17	View
4008395	chr11	7	1	7	15	View
4009295	chr11	12			12	View
4011353	chr11	5	2		7	View
4015501	chr11		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PPP6R3 expression and immune infiltrating cell level correlation result in HIV+ samples
PPP6R3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).