HIV Target gene Detail Information

> PPP1CB Gene Search Result

Gene Information

Gene Name	PPP1CB
Gene ID	5500
Gene Full Name	protein phosphatase 1 catalytic subunit beta
Gene Alias	PP1B; NSLH2; PP-1B; PPP1CD; PP1beta; HEL-S-80p
Transcripts	ENSG00000213639
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P62140
HGNC ID	HGNC:9282
VEGA ID	OTTHUMG00000152011
OMIM ID	600590
String ID	9606.ENSP00000378769
PharmGKB ID	PA33610

Target gene [PPP1CB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003193	chr2	59	5	3	67	View
4003274	chr2	64	1		65	View
4009246	chr2	2	7	3	12	View
4014419	chr2	1	1		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PPP1CB expression and immune infiltrating cell level correlation result in HIV+ samples
PPP1CB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PPP1CB expression and immune infiltrating cell level correlation result in HIV+ samples
PPP1CB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).