HTLV1 Target gene Detail Information

> PPM1M Gene Search Result


Gene Information
Gene Name PPM1M
Gene ID 132160
Gene Full Name protein phosphatase, Mg2+/Mn2+ dependent 1M
Gene Alias PP2CE; PP2Ceta; PP2C-eta
Transcripts ENSG00000164088
Virus HTLV1
Gene Type protein coding
HPA Location Info Nuclear bodies;
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Uniport_ID Q96MI6
HGNC ID HGNC:26506
VEGA ID OTTHUMG00000153046
OMIM ID 608979
String ID 9606.ENSP00000387046
PharmGKB ID PA142671151
Target gene [PPM1M] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6005089 chr3 49 31 16 96 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PPM1M expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPM1M expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PPM1M expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPM1M expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PPM1M expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPM1M expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).