HBV Target gene Detail Information

> PPM1L Gene Search Result

Gene Information

Gene Name	PPM1L
Gene ID	151742
Gene Full Name	protein phosphatase, Mg2+/Mn2+ dependent 1L
Gene Alias	PP2CE; PPM1-LIKE; PP2C-epsilon
Transcripts	ENSG00000163590
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q5SGD2
HGNC ID	HGNC:16381
VEGA ID	OTTHUMG00000159048
OMIM ID	611931
String ID	9606.ENSP00000417659
PharmGKB ID	PA134871016

Target gene [PPM1L] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1012048	chr3	7			7	View
1017136	chr3	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PPM1L expression and immune infiltrating cell level correlation result in HBV+ samples
PPM1L expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).