HTLV1 Target gene Detail Information

> PPM1K Gene Search Result


Gene Information
Gene Name PPM1K
Gene ID 152926
Gene Full Name protein phosphatase, Mg2+/Mn2+ dependent 1K
Gene Alias BDP; PTMP; PP2Cm; MSUDMV; PP2Ckappa; UG0882E07
Transcripts ENSG00000163644
Virus HTLV1
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q8N3J5
HGNC ID HGNC:25415
VEGA ID OTTHUMG00000130952
OMIM ID 611065
String ID 9606.ENSP00000477341
PharmGKB ID PA134912083
Target gene [PPM1K] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6004203 chr4 94 29 2 125 View
6022140 chr4 2 1 2 5 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PPM1K expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPM1K expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PPM1K expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPM1K expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PPM1K expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPM1K expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).