HTLV1 Target gene Detail Information

> PPL Gene Search Result

Gene Information

Gene Name	PPL
Gene ID	5493
Gene Full Name	periplakin
Transcripts	ENSG00000118898
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Plasma membrane;Cytosol;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	O60437
HGNC ID	HGNC:9273
VEGA ID	OTTHUMG00000129528
OMIM ID	602871
String ID	9606.ENSP00000340510
PharmGKB ID	PA33602

Target gene [PPL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001377	chr16	123	145	190	458	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PPL expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPL expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PPL expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPL expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PPL expression and immune infiltrating cell level correlation result in HTLV1+ samples
PPL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).