HIV Target gene Detail Information

> POLR3B Gene Search Result

Gene Information

Gene Name	POLR3B
Gene ID	55703
Gene Full Name	RNA polymerase III subunit B
Gene Alias	C128; HLD8; RPC2; INMAP
Transcripts	ENSG00000013503
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RNA polymerase related proteins
Uniport_ID	Q9NW08
HGNC ID	HGNC:30348
VEGA ID	OTTHUMG00000170077
OMIM ID	614366
String ID	9606.ENSP00000228347
PharmGKB ID	PA134867680

Target gene [POLR3B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4013583	chr12		3		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of POLR3B expression and immune infiltrating cell level correlation result in HIV+ samples
POLR3B expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of POLR3B expression and immune infiltrating cell level correlation result in HIV+ samples
POLR3B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).