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HBV Target gene Detail Information

> POLR2H Gene Search Result


Gene Information
Gene Name POLR2H
Gene ID 5437
Gene Full Name RNA polymerase II subunit H
Gene Alias RPB8; RPB17; RPABC3
Transcripts ENSG00000163882
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Predicted intracellular proteins, RNA polymerase related proteins
Uniport_ID P52434
HGNC ID HGNC:9195
VEGA ID OTTHUMG00000156746
OMIM ID 606023
String ID 9606.ENSP00000415536
PharmGKB ID PA33515
Target gene [POLR2H] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001677 chr3 240 71 241 552 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of POLR2H expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
POLR2H expression: Low -> High
Lollipop of POLR2H expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of POLR2H expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of POLR2H expression and immune infiltrating cell level correlation result in HBV+ samples
POLR2H expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).