HIV Target gene Detail Information

> POLR2E Gene Search Result

Gene Information

Gene Name	POLR2E
Gene ID	5434
Gene Full Name	RNA polymerase II subunit E
Gene Alias	RPB5; XAP4; RPABC1; hRPB25; hsRPB5
Transcripts	ENSG00000099817
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins, RNA polymerase related proteins
Uniport_ID	P19388
HGNC ID	HGNC:9192
VEGA ID	OTTHUMG00000181873
OMIM ID	180664
String ID	9606.ENSP00000478303
PharmGKB ID	PA33512

Target gene [POLR2E] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005002	chr19	37			37	View
4007667	chr19	18			18	View
4008159	chr19	16			16	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of POLR2E expression and immune infiltrating cell level correlation result in HIV+ samples
POLR2E expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of POLR2E expression and immune infiltrating cell level correlation result in HIV+ samples
POLR2E expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).