HIV Target gene Detail Information

> POLR2A Gene Search Result

Gene Information

Gene Name	POLR2A
Gene ID	5430
Gene Full Name	RNA polymerase II subunit A
Gene Alias	RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; RpIILS; hsRPB1; hRPB220
Transcripts	ENSG00000284832
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	P24928
HGNC ID	HGNC:9187
VEGA ID	OTTHUMG00000177594
OMIM ID	180660
String ID	9606.ENSP00000480158
PharmGKB ID	PA33507

Target gene [POLR2A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000433	chr17	218	246	2	466	View
4001491	chr17	20	138		158	View
4005064	chr17	4	32		36	View
4005604	chr17	20	11		31	View
4005825	chr17	4	25		29	View
4006411	chr17	25			25	View
4009498	chr17	11			11	View
4009736	chr17	11			11	View
4010565	chr17	5		3	8	View
4010957	chr17	6	1	1	8	View
4011062	chr17	6	1		7	View
4012250	chr17	4	1		5	View
4013443	chr17	2	1		3	View
4013622	chr17	1	2		3	View
4013623	chr17	2	1		3	View
4015173	chr17		1		1	View
4015980	chr17				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of POLR2A expression and immune infiltrating cell level correlation result in HIV+ samples
POLR2A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of POLR2A expression and immune infiltrating cell level correlation result in HIV+ samples
POLR2A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).