HIV Target gene Detail Information

> POLH Gene Search Result

Gene Information

Gene Name	POLH
Gene ID	5429
Gene Full Name	DNA polymerase eta
Gene Alias	XPV; XP-V; RAD30; RAD30A
Transcripts	ENSG00000170734
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q9Y253
HGNC ID	HGNC:9181
VEGA ID	OTTHUMG00000014743
OMIM ID	603968
String ID	9606.ENSP00000361310
PharmGKB ID	PA279

Target gene [POLH] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005924	chr6	19	3	6	28	View
4007742	chr6	5	11	2	18	View
4015829	chr6		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of POLH expression and immune infiltrating cell level correlation result in HIV+ samples
POLH expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of POLH expression and immune infiltrating cell level correlation result in HIV+ samples
POLH expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).