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HTLV1 Target gene Detail Information

> POLG Gene Search Result


Gene Information
Gene Name POLG
Gene ID 5428
Gene Full Name DNA polymerase gamma, catalytic subunit
Gene Alias PEO; MDP1; SCAE; MIRAS; POLG1; POLGA; SANDO; MTDPS4A; MTDPS4B
Transcripts ENSG00000140521
Virus HTLV1
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID P54098
HGNC ID HGNC:9179
VEGA ID OTTHUMG00000149646
OMIM ID 174763
String ID 9606.ENSP00000268124
PharmGKB ID PA33500
FDA Approved Drug Valproic Acid
Target gene [POLG] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6010148 chr15 28 5 33 View
6011888 chr2 22 2 24 View
6014545 chr2 7 8 1 16 View
6015183 chr2 3 6 6 15 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of POLG expression and immune infiltrating cell level correlation result in HTLV1+ samples
POLG expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of POLG expression and immune infiltrating cell level correlation result in HTLV1+ samples
POLG expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of POLG expression and immune infiltrating cell level correlation result in HTLV1+ samples
POLG expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).