HIV Target gene Detail Information

> POLE Gene Search Result

Gene Information

Gene Name	POLE
Gene ID	5426
Gene Full Name	DNA polymerase epsilon, catalytic subunit
Gene Alias	FILS; POLE1; CRCS12
Transcripts	ENSG00000177084
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q07864
HGNC ID	HGNC:9177
VEGA ID	OTTHUMG00000168045
OMIM ID	174762
String ID	9606.ENSP00000322570
Drugbank ID	BE0003614
PharmGKB ID	PA277

Target gene [POLE] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004381	chr12	24	6	15	45	View
4011195	chr12	6	1		7	View
4016076	chr12				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of POLE expression and immune infiltrating cell level correlation result in HIV+ samples
POLE expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of POLE expression and immune infiltrating cell level correlation result in HIV+ samples
POLE expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).