HIV Target gene Detail Information

> POLD1 Gene Search Result

Gene Information

Gene Name	POLD1
Gene ID	5424
Gene Full Name	DNA polymerase delta 1, catalytic subunit
Gene Alias	CDC2; MDPL; POLD; CRCS10
Transcripts	ENSG00000062822
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P28340
HGNC ID	HGNC:9175
VEGA ID	OTTHUMG00000183037
OMIM ID	174761
String ID	9606.ENSP00000406046
PharmGKB ID	PA33496

Target gene [POLD1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4009111	chr19	10	2		12	View
4010179	chr12	9			9	View
4010724	chr19	6	2		8	View
4011601	chr19	6			6	View
4014277	chr19	2			2	View
4015324	chr19	1			1	View
4016274	chr19				0	View
4300068	chr12	14	2	1	17	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of POLD1 expression and immune infiltrating cell level correlation result in HIV+ samples
POLD1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of POLD1 expression and immune infiltrating cell level correlation result in HIV+ samples
POLD1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).