HTLV1 Target gene Detail Information

> PNPO Gene Search Result

Gene Information

Gene Name	PNPO
Gene ID	55163
Gene Full Name	pyridoxamine 5'-phosphate oxidase
Gene Alias	PDXPO; HEL-S-302
Transcripts	ENSG00000108439
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q9NVS9
HGNC ID	HGNC:30260
VEGA ID	OTTHUMG00000178295
OMIM ID	603287
String ID	9606.ENSP00000225573
Drugbank ID	BE0000181
PharmGKB ID	PA134915565

Target gene [PNPO] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6008595	chr17	33	11		44	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PNPO expression and immune infiltrating cell level correlation result in HTLV1+ samples
PNPO expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PNPO expression and immune infiltrating cell level correlation result in HTLV1+ samples
PNPO expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PNPO expression and immune infiltrating cell level correlation result in HTLV1+ samples
PNPO expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).