HTLV1 Target gene Detail Information

> PNPLA3 Gene Search Result

Gene Information

Gene Name	PNPLA3
Gene ID	80339
Gene Full Name	patatin like phospholipase domain containing 3
Gene Alias	ADPN; C22orf20; iPLA(2)epsilon
Transcripts	ENSG00000100344
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoli;Cytosol;Mitochondria;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q9NST1
HGNC ID	HGNC:18590
VEGA ID	OTTHUMG00000150555
OMIM ID	609567
String ID	9606.ENSP00000216180
PharmGKB ID	PA38592

Target gene [PNPLA3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000806	chr22	197	457	178	832	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PNPLA3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PNPLA3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PNPLA3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PNPLA3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).