HIV Target gene Detail Information

> PNKP Gene Search Result

Gene Information

Gene Name	PNKP
Gene ID	11284
Gene Full Name	polynucleotide kinase 3'-phosphatase
Gene Alias	PNK; AOA4; MCSZ; EIEE10
Transcripts	ENSG00000039650
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q96T60
HGNC ID	HGNC:9154
VEGA ID	OTTHUMG00000183261
OMIM ID	605610
String ID	9606.ENSP00000323511
PharmGKB ID	PA33477

Target gene [PNKP] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002083	chr19	97	16		113	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PNKP expression and immune infiltrating cell level correlation result in HIV+ samples
PNKP expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PNKP expression and immune infiltrating cell level correlation result in HIV+ samples
PNKP expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).