HIV Target gene Detail Information

> PML Gene Search Result

Gene Information

Gene Name	PML
Gene ID	5371
Gene Full Name	promyelocytic leukemia
Gene Alias	MYL; RNF71; PP8675; TRIM19
Transcripts	ENSG00000140464
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear bodies;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	P29590
HGNC ID	HGNC:9113
VEGA ID	OTTHUMG00000137607
OMIM ID	102578
String ID	9606.ENSP00000268058
Drugbank ID	BE0005855; BE0005808
PharmGKB ID	PA33439

Target gene [PML] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000704	chr15	302	4	4	310	View
4002593	chr15	52	33	3	88	View
4003844	chr15	16	31	6	53	View
4007968	chr15	13	4		17	View
4013862	chr15	2	1		3	View
4014381	chr15	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PML expression and immune infiltrating cell level correlation result in HIV+ samples
PML expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PML expression and immune infiltrating cell level correlation result in HIV+ samples
PML expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).