HBV Target gene Detail Information

> PLOD2 Gene Search Result

Gene Information

Gene Name	PLOD2
Gene ID	5352
Gene Full Name	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Gene Alias	LH2; TLH; BRKS2
Transcripts	ENSG00000152952
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoli;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	O00469
HGNC ID	HGNC:9082
VEGA ID	OTTHUMG00000159417
OMIM ID	601865
String ID	9606.ENSP00000282903
Drugbank ID	BE0002192
PharmGKB ID	PA33412

Target gene [PLOD2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004876	chr3	15	18	34	67	View
1006385	chr3	8	10	21	39	View
1013003	chr3		4	2	6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PLOD2 expression and immune infiltrating cell level correlation result in HBV+ samples
PLOD2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).