HTLV1 Target gene Detail Information

> PLEKHG3 Gene Search Result

Gene Information

Gene Name	PLEKHG3
Gene ID	26030
Gene Full Name	pleckstrin homology and RhoGEF domain containing G3
Gene Alias	ARHGEF43; KIAA0599
Transcripts	ENSG00000126822
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;Centrosome;Cytokinetic bridge;Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	A1L390
HGNC ID	HGNC:20364
VEGA ID	OTTHUMG00000029671
OMIM ID	617940
String ID	9606.ENSP00000247226
PharmGKB ID	PA134925358

Target gene [PLEKHG3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001077	chr14	79	219	299	597	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PLEKHG3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHG3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PLEKHG3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHG3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PLEKHG3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHG3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).