HIV Target gene Detail Information

> PLEKHG1 Gene Search Result

Gene Information

Gene Name	PLEKHG1
Gene ID	57480
Gene Full Name	pleckstrin homology and RhoGEF domain containing G1
Gene Alias	ARHGEF41
Transcripts	ENSG00000120278
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9ULL1
HGNC ID	HGNC:20884
VEGA ID	OTTHUMG00000015824
String ID	9606.ENSP00000356297
PharmGKB ID	PA134922441

Target gene [PLEKHG1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4013024	chr6	3	1		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PLEKHG1 expression and immune infiltrating cell level correlation result in HIV+ samples
PLEKHG1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PLEKHG1 expression and immune infiltrating cell level correlation result in HIV+ samples
PLEKHG1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).