HTLV1 Target gene Detail Information

> PLEKHA8 Gene Search Result

Gene Information

Gene Name	PLEKHA8
Gene ID	84725
Gene Full Name	pleckstrin homology domain containing A8
Gene Alias	FAPP2
Transcripts	ENSG00000106086
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q96JA3
HGNC ID	HGNC:30037
VEGA ID	OTTHUMG00000097751
OMIM ID	608639
String ID	9606.ENSP00000397947
PharmGKB ID	PA134926954

Target gene [PLEKHA8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002103	chr7	8	261	16	285	View
6015117	chr7	8	3	4	15	View
6015118	chr7	8	3	4	15	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA8 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA8 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).