HTLV1 Target gene Detail Information

> PLEKHA7 Gene Search Result

Gene Information

Gene Name	PLEKHA7
Gene ID	144100
Gene Full Name	pleckstrin homology domain containing A7
Transcripts	ENSG00000166689
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cell Junctions;Nucleoplasm;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q6IQ23
HGNC ID	HGNC:27049
VEGA ID	OTTHUMG00000165954
OMIM ID	612686
String ID	9606.ENSP00000347883
PharmGKB ID	PA134894945

Target gene [PLEKHA7] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001720	chr11	246	52	62	360	View
6003154	chr11	134	40	4	178	View
6003169	chr11	140	25	13	178	View
6003269	chr11	132	26	12	170	View
6003332	chr11	128	26	12	166	View
6003427	chr11	125	25	10	160	View
6009410	chr11	22	11	4	37	View
6013033	chr11	16	4		20	View
6019376	chr11	4	1	3	8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA7 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA7 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA7 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA7 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA7 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA7 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).