HTLV1 Target gene Detail Information

> PLEKHA4 Gene Search Result

Gene Information

Gene Name	PLEKHA4
Gene ID	57664
Gene Full Name	pleckstrin homology domain containing A4
Gene Alias	PEPP1
Transcripts	ENSG00000105559
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;Centriolar satellite;Cytokinetic bridge;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9H4M7
HGNC ID	HGNC:14339
VEGA ID	OTTHUMG00000183329
OMIM ID	607769
String ID	9606.ENSP00000263265
Drugbank ID	BE0001278
PharmGKB ID	PA33404

Target gene [PLEKHA4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6016148	chr19	13			13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA4 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA4 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEKHA4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).