HIV Target gene Detail Information

> PLEKHA1 Gene Search Result

Gene Information

Gene Name	PLEKHA1
Gene ID	59338
Gene Full Name	pleckstrin homology domain containing A1
Gene Alias	TAPP1
Transcripts	ENSG00000107679
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9HB21
HGNC ID	HGNC:14335
VEGA ID	OTTHUMG00000019184
OMIM ID	607772
String ID	9606.ENSP00000357986
Drugbank ID	BE0003262
PharmGKB ID	PA33401

Target gene [PLEKHA1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003214	chr10	44	6	16	66	View
4003577	chr10	56	2		58	View
4004713	chr10	3	1	36	40	View
4005377	chr10	15	10	8	33	View
4005550	chr10	12	7	12	31	View
4009202	chr10	9	3		12	View
4012689	chr10	2	2		4	View
4013418	chr10	2	1		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA1 expression and immune infiltrating cell level correlation result in HIV+ samples
PLEKHA1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PLEKHA1 expression and immune infiltrating cell level correlation result in HIV+ samples
PLEKHA1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).