HTLV1 Target gene Detail Information

> PLEK Gene Search Result

Gene Information

Gene Name	PLEK
Gene ID	5341
Gene Full Name	pleckstrin
Gene Alias	P47
Transcripts	ENSG00000115956
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoli;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	P08567
HGNC ID	HGNC:9070
VEGA ID	OTTHUMG00000129562
OMIM ID	173570
String ID	9606.ENSP00000234313
PharmGKB ID	PA33400

Target gene [PLEK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002641	chr2	9	116	97	222	View
6010261	chr2	32			32	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PLEK expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEK expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PLEK expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEK expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PLEK expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLEK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).