HIV Target gene Detail Information

> PLEC Gene Search Result

Gene Information

Gene Name	PLEC
Gene ID	5339
Gene Full Name	plectin
Gene Alias	HD1; PCN; EBS1; EBSO; PLTN; EBSMD; EBSND; EBSOG; EBSPA; PLEC1; LGMD2Q; PLEC1b; LGMDR17
Transcripts	ENSG00000178209
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Intermediate filaments;Focal adhesion sites;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q15149
HGNC ID	HGNC:9069
VEGA ID	OTTHUMG00000165291
OMIM ID	601282
String ID	9606.ENSP00000323856
PharmGKB ID	PA33399

Target gene [PLEC] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000769	chr8	28	245	13	286	View
4000911	chr8	51	98	101	250	View
4001375	chr8	65	69	38	172	View
4002923	chr8	9	61	5	75	View
4003212	chr8	60	6		66	View
4003465	chr8	52	3	6	61	View
4005080	chr8	5	31		36	View
4005367	chr8	29	1		30	View
4005581	chr8	31			31	View
4006902	chr8	21	1		22	View
4008631	chr8	7	7		14	View
4011800	chr8	4	2		6	View
4013936	chr8	2	1		3	View
4015760	chr8	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PLEC expression and immune infiltrating cell level correlation result in HIV+ samples
PLEC expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).