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HTLV1 Target gene Detail Information

> PLD3 Gene Search Result


Gene Information
Gene Name PLD3
Gene ID 23646
Gene Full Name phospholipase D family member 3
Gene Alias AD19; HUK4; HU-K4; SCA46
Transcripts ENSG00000105223
Virus HTLV1
Gene Type protein coding
HPA Location Info Cytosol;Endoplasmic reticulum;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q8IV08
HGNC ID HGNC:17158
VEGA ID OTTHUMG00000152736
OMIM ID 615698
String ID 9606.ENSP00000387050
PharmGKB ID PA134887482
Target gene [PLD3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6006494 chr19 51 14 3 68 View
6006495 chr19 51 14 3 68 View
6020873 chr19 5 1 6 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PLD3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLD3 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PLD3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLD3 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PLD3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLD3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).