HIV Target gene Detail Information

> PLCG1 Gene Search Result

Gene Information

Gene Name	PLCG1
Gene ID	5335
Gene Full Name	phospholipase C gamma 1
Gene Alias	PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
Transcripts	ENSG00000124181
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	P19174
HGNC ID	HGNC:9065
VEGA ID	OTTHUMG00000033082
OMIM ID	172420
String ID	9606.ENSP00000244007
PharmGKB ID	PA33392

Target gene [PLCG1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008350	chr20	13	1	1	15	View
4015180	chr20		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PLCG1 expression and immune infiltrating cell level correlation result in HIV+ samples
PLCG1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PLCG1 expression and immune infiltrating cell level correlation result in HIV+ samples
PLCG1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).