HBV Target gene Detail Information

> PLCB4 Gene Search Result

Gene Information

Gene Name	PLCB4
Gene ID	5332
Gene Full Name	phospholipase C beta 4
Gene Alias	ARCND2; PI-PLC
Transcripts	ENSG00000101333
Virus	HBV
Gene Type	protein coding
HPA Location Info	Microtubules;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q15147
HGNC ID	HGNC:9059
VEGA ID	OTTHUMG00000031853
OMIM ID	600810
String ID	9606.ENSP00000367762
PharmGKB ID	PA33387

Target gene [PLCB4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1010733	chr20	6	1	4	11	View
1016622	chr20		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PLCB4 expression and immune infiltrating cell level correlation result in HBV+ samples
PLCB4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).