HTLV1 Target gene Detail Information

> PLCB2 Gene Search Result


Gene Information
Gene Name PLCB2
Gene ID 5330
Gene Full Name phospholipase C beta 2
Gene Alias PLC-beta-2
Transcripts ENSG00000137841
Virus HTLV1
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Uniport_ID Q00722
HGNC ID HGNC:9055
VEGA ID OTTHUMG00000172412
OMIM ID 604114
String ID 9606.ENSP00000260402
PharmGKB ID PA33385
Target gene [PLCB2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6007259 chr15 14 20 24 58 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PLCB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLCB2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PLCB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLCB2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PLCB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLCB2 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).