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HTLV1 Target gene Detail Information

> PLAT Gene Search Result


Gene Information
Gene Name PLAT
Gene ID 5327
Gene Full Name plasminogen activator, tissue type
Gene Alias TPA; T-PA
Transcripts ENSG00000104368
Virus HTLV1
Gene Type protein coding
HPA Location Info Actin filaments;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Uniport_ID P00750
HGNC ID HGNC:9051
VEGA ID OTTHUMG00000164072
OMIM ID 173370
String ID 9606.ENSP00000220809
Drugbank ID BE0001088
PharmGKB ID PA33381
Target gene [PLAT] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6007471 chr8 42 13 55 View
6010417 chr8 28 3 31 View
6018258 chr8 4 5 9 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PLAT expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLAT expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PLAT expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLAT expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PLAT expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLAT expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).