HTLV1 Target gene Detail Information

> PLA2G7 Gene Search Result

Gene Information

Gene Name	PLA2G7
Gene ID	7941
Gene Full Name	phospholipase A2 group VII
Gene Alias	PAFAD; PAFAH; LP-PLA2; LDL-PLA2
Transcripts	ENSG00000146070
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins
Gene Function	Suppressor gene
Uniport_ID	Q13093
HGNC ID	HGNC:9040
VEGA ID	OTTHUMG00000014789
OMIM ID	601690
String ID	9606.ENSP00000274793
Drugbank ID	BE0002409
PharmGKB ID	PA33368

Target gene [PLA2G7] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006799	chr6	40	8	15	63	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PLA2G7 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLA2G7 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PLA2G7 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLA2G7 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PLA2G7 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLA2G7 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).