HIV Target gene Detail Information

> PLA2G6 Gene Search Result

Gene Information

Gene Name	PLA2G6
Gene ID	8398
Gene Full Name	phospholipase A2 group VI
Gene Alias	GVI; PLA2; INAD1; NBIA2; iPLA2; NBIA2A; NBIA2B; PARK14; PNPLA9; CaI-PLA2; IPLA2-VIA; iPLA2beta
Transcripts	ENSG00000184381
Virus	HIV
Gene Type	protein coding
HPA Location Info	Centriolar satellite;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Uniport_ID	O60733
HGNC ID	HGNC:9039
VEGA ID	OTTHUMG00000151246
OMIM ID	603604
String ID	9606.ENSP00000333142
Drugbank ID	BE0001077
PharmGKB ID	PA33367

Target gene [PLA2G6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4007980	chr22	9	7	1	17	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PLA2G6 expression and immune infiltrating cell level correlation result in HIV+ samples
PLA2G6 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PLA2G6 expression and immune infiltrating cell level correlation result in HIV+ samples
PLA2G6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).