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HPV Target gene Detail Information

> PLA2G2A Gene Search Result


Gene Information
Gene Name PLA2G2A
Gene ID 5320
Gene Full Name phospholipase A2 group IIA
Gene Alias MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
Transcripts ENSG00000188257
Virus HPV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Enzymes, FDA approved drug targets, Predicted secreted proteins, RAS pathway related proteins
Gene Function Suppressor gene
Uniport_ID P14555
HGNC ID HGNC:9031
VEGA ID OTTHUMG00000002699
OMIM ID 172411
String ID 9606.ENSP00000383364
Drugbank ID BE0001640
PharmGKB ID PA270
Target gene [PLA2G2A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5201490 chr1 32 25 57 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of PLA2G2A expression and immune infiltrating cell level correlation result in HPV+ samples
PLA2G2A expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of PLA2G2A expression and immune infiltrating cell level correlation result in HPV+ samples
PLA2G2A expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of PLA2G2A expression and immune infiltrating cell level correlation result in HPV+ samples
PLA2G2A expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of PLA2G2A expression and immune infiltrating cell level correlation result in HPV+ samples
PLA2G2A expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of PLA2G2A expression and immune infiltrating cell level correlation result in HPV+ samples
PLA2G2A expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of PLA2G2A expression and immune infiltrating cell level correlation result in HPV+ samples
PLA2G2A expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of PLA2G2A expression and immune infiltrating cell level correlation result in HPV+ samples
PLA2G2A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).