HIV Target gene Detail Information

> PKN2 Gene Search Result

Gene Information

Gene Name	PKN2
Gene ID	5586
Gene Full Name	protein kinase N2
Gene Alias	PAK2; PRK2; STK7; Pak-2; PRKCL2; PRO2042
Transcripts	ENSG00000065243
Virus	HIV
Gene Type	protein coding
HPA Location Info	Intermediate filaments;Nucleoplasm;Centrosome;Cytosol;Nuclear bodies;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q16513
HGNC ID	HGNC:9406
VEGA ID	OTTHUMG00000010074
OMIM ID	602549
String ID	9606.ENSP00000359552
Drugbank ID	BE0009475
PharmGKB ID	PA33770

Target gene [PKN2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4014112	chr1		2		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PKN2 expression and immune infiltrating cell level correlation result in HIV+ samples
PKN2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PKN2 expression and immune infiltrating cell level correlation result in HIV+ samples
PKN2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).