HIV Target gene Detail Information

> PKIA Gene Search Result

Gene Information

Gene Name	PKIA
Gene ID	5569
Gene Full Name	cAMP-dependent protein kinase inhibitor alpha
Gene Alias	PRKACN1
Transcripts	ENSG00000171033
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	P61925
HGNC ID	HGNC:9017
VEGA ID	OTTHUMG00000164618
OMIM ID	606059
String ID	9606.ENSP00000379696
Drugbank ID	BE0003762
PharmGKB ID	PA33349

Target gene [PKIA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010227	chr8	7	2		9	View
4014989	chr8	1			1	View
4016106	chr8				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PKIA expression and immune infiltrating cell level correlation result in HIV+ samples
PKIA expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PKIA expression and immune infiltrating cell level correlation result in HIV+ samples
PKIA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).