HTLV1 Target gene Detail Information

> PIP5K1C Gene Search Result

Gene Information

Gene Name	PIP5K1C
Gene ID	23396
Gene Full Name	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
Gene Alias	LCCS3; PIP5Kgamma; PIP5K-GAMMA; PIP5K1-gamma
Transcripts	ENSG00000186111
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	O60331
HGNC ID	HGNC:8996
VEGA ID	OTTHUMG00000180870
OMIM ID	606102
String ID	9606.ENSP00000466363
PharmGKB ID	PA33329

Target gene [PIP5K1C] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001887	chr19	192	97	33	322	View
6004513	chr19	109	4		113	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PIP5K1C expression and immune infiltrating cell level correlation result in HTLV1+ samples
PIP5K1C expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PIP5K1C expression and immune infiltrating cell level correlation result in HTLV1+ samples
PIP5K1C expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PIP5K1C expression and immune infiltrating cell level correlation result in HTLV1+ samples
PIP5K1C expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).