HIV Target gene Detail Information

> PIP4K2C Gene Search Result

Gene Information

Gene Name	PIP4K2C
Gene ID	79837
Gene Full Name	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Gene Alias	PIP5K2C
Transcripts	ENSG00000166908
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q8TBX8
HGNC ID	HGNC:23786
VEGA ID	OTTHUMG00000170144
OMIM ID	617104
String ID	9606.ENSP00000347032
Drugbank ID	BE0009472; BE0009518
Drug (Cytoscape Annotation)	Pazopanib Hydrochloride;ImatinibMesylate;ErlotinibHydrochloride
PharmGKB ID	PA162399665

Target gene [PIP4K2C] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4013580	chr12	2	1		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PIP4K2C expression and immune infiltrating cell level correlation result in HIV+ samples
PIP4K2C expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PIP4K2C expression and immune infiltrating cell level correlation result in HIV+ samples
PIP4K2C expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).