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HIV Target gene Detail Information

> PIK3R2 Gene Search Result


Gene Information
Gene Name PIK3R2
Gene ID 5296
Gene Full Name phosphoinositide-3-kinase regulatory subunit 2
Gene Alias p85; MPPH; P85B; MPPH1; p85-BETA
Transcripts ENSG00000105647
Virus HIV
Gene Type protein coding
HPA Location Info Golgi apparatus;
HPA Protein Class Info Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID O00459
HGNC ID HGNC:8980
VEGA ID OTTHUMG00000183383
OMIM ID 603157
String ID 9606.ENSP00000222254
Drugbank ID BE0002383
PharmGKB ID PA33313
Target gene [PIK3R2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000183 chr19 58 464 293 815 View
4001150 chr19 48 131 29 208 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of PIK3R2 expression and immune infiltrating cell level correlation result in HIV+ samples
PIK3R2 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of PIK3R2 expression and immune infiltrating cell level correlation result in HIV+ samples
PIK3R2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).