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HBV Target gene Detail Information

> PIK3R1 Gene Search Result


Gene Information
Gene Name PIK3R1
Gene ID 5295
Gene Full Name phosphoinositide-3-kinase regulatory subunit 1
Gene Alias p85; AGM7; GRB1; IMD36; p85-ALPHA
Transcripts ENSG00000145675
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;
HPA Protein Class Info Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Gene Function Oncogene
Uniport_ID P27986
HGNC ID HGNC:8979
VEGA ID OTTHUMG00000131251
OMIM ID 171833
String ID 9606.ENSP00000428056
Drugbank ID BE0000955
PharmGKB ID PA33312
Target gene [PIK3R1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001658 chr5 56 185 302 543 View
1002926 chr5 28 74 88 190 View
1007027 chr5 26 4 1 31 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PIK3R1 expression and immune infiltrating cell level correlation result in HBV+ samples
PIK3R1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).