HPV Target gene Detail Information

> PHOX2A Gene Search Result

Gene Information

Gene Name	PHOX2A
Gene ID	401
Gene Full Name	paired like homeobox 2A
Gene Alias	ARIX; FEOM2; NCAM2; PMX2A; CFEOM2
Transcripts	ENSG00000165462
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	O14813
HGNC ID	HGNC:691
VEGA ID	OTTHUMG00000167899
OMIM ID	602753
String ID	9606.ENSP00000298231
PharmGKB ID	PA28093

Target gene [PHOX2A] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	28767682	A7729C	LCR	G R S C	View
2	28767682	A7730C	LCR	G R S C	View
3	28767682	T7743G	LCR	G R S C	View

Target gene [PHOX2A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5402818	chr11	2	1		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of PHOX2A expression and immune infiltrating cell level correlation result in HPV+ samples
PHOX2A expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of PHOX2A expression and immune infiltrating cell level correlation result in HPV+ samples
PHOX2A expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of PHOX2A expression and immune infiltrating cell level correlation result in HPV+ samples
PHOX2A expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of PHOX2A expression and immune infiltrating cell level correlation result in HPV+ samples
PHOX2A expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of PHOX2A expression and immune infiltrating cell level correlation result in HPV+ samples
PHOX2A expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of PHOX2A expression and immune infiltrating cell level correlation result in HPV+ samples
PHOX2A expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of PHOX2A expression and immune infiltrating cell level correlation result in HPV+ samples
PHOX2A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662