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EBV Target gene Detail Information

> PHLDB2 Gene Search Result


Gene Information
Gene Name PHLDB2
Gene ID 90102
Gene Full Name pleckstrin homology like domain family B member 2
Gene Alias LL5b; LL5beta
Transcripts ENSG00000144824
Virus EBV
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q86SQ0
HGNC ID HGNC:29573
VEGA ID OTTHUMG00000159282
OMIM ID 610298
String ID 9606.ENSP00000405405
PharmGKB ID PA134884060
Target gene [PHLDB2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
3000061 chr3 16 134 215 365 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE102203 (GEO) B-cell lymphoma 9 Plasmablastic lymphomas (EBV+)(6), Plasmablastic lymphomas (EBV-)(3)
GSE100458 (GEO) Burkitt lymphoma 14 Burkitt lyphoma cell line Akata(EBV+)(2),Burkitt lyphoma cell line Akata(EBV-)(2),Burkitt lyphoma cell line Awia(EBV+)(2),Burkitt lyphoma cell line Awia(EBV-)(2),Burkitt lyphoma cell line Eli(EBV+)(1),Burkitt lyphoma cell line Eli(EBV-)(1),Burkitt lyphoma cell line Mutu(EBV+)(2),Burkitt lyphoma cell line Mutu(EBV-)(2)
GSE42867 (GEO) Burkitt lymphoma 12 Burkitt lymphoma cell line Awia (EBV+)(12)
GSE135644 (GEO) Gastric carcinoma 10 Gastric adenocarcinoma cell line AGS (5), Gastric adenocarcinoma cell line AGS (EBV+)(5)
GSE45919 (GEO) Infectious mononucleosis 24 Infectious mononucleosis (IM)(EBV+)(3), Normal (9), Latent EBV (12)
GSE85599 (GEO) Infectious mononucleosis 17 Chronic active EBV infection (EBV+)(5), Acute infectious mononucleosis (EBV+)(6), Normal (6)
GSE58240 (GEO) Multiple sclerosis 32 Multiple sclerosis IFN-β treated (EBV+)(16), Multiple sclerosis untreated (EBV+)(16)
GSE12452 (GEO) Nasopharyngeal carcinoma 41 Nasopharyngeal carcinoma (EBV+)(31), Normal(10)

> Dataset: GSE102203

HeatMap of cell type fractions in all samples Lollipop of PHLDB2 expression and immune infiltrating cell level correlation result in EBV+ samples
PHLDB2 expression: Low -> High

> Dataset: GSE100458

HeatMap of cell type fractions in all samples Lollipop of PHLDB2 expression and immune infiltrating cell level correlation result in EBV+ samples
PHLDB2 expression: Low -> High

> Dataset: GSE42867

HeatMap of cell type fractions in all samples Lollipop of PHLDB2 expression and immune infiltrating cell level correlation result in EBV+ samples
PHLDB2 expression: Low -> High

> Dataset: GSE135644

HeatMap of cell type fractions in all samples Lollipop of PHLDB2 expression and immune infiltrating cell level correlation result in EBV+ samples
PHLDB2 expression: Low -> High

> Dataset: GSE45919

HeatMap of cell type fractions in all samples Lollipop of PHLDB2 expression and immune infiltrating cell level correlation result in EBV+ samples
PHLDB2 expression: Low -> High

> Dataset: GSE85599

HeatMap of cell type fractions in all samples Lollipop of PHLDB2 expression and immune infiltrating cell level correlation result in EBV+ samples
PHLDB2 expression: Low -> High

> Dataset: GSE58240

HeatMap of cell type fractions in all samples Lollipop of PHLDB2 expression and immune infiltrating cell level correlation result in EBV+ samples
PHLDB2 expression: Low -> High

> Dataset: GSE12452

HeatMap of cell type fractions in all samples Lollipop of PHLDB2 expression and immune infiltrating cell level correlation result in EBV+ samples
PHLDB2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).