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HTLV1 Target gene Detail Information

> PHKA2 Gene Search Result


Gene Information
Gene Name PHKA2
Gene ID 5256
Gene Full Name phosphorylase kinase regulatory subunit alpha 2
Gene Alias PHK; PYK; XLG; PYKL; XLG2; GSD9A
Transcripts ENSG00000044446
Virus HTLV1
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Disease related genes, Predicted intracellular proteins
Uniport_ID P46019
HGNC ID HGNC:8926
VEGA ID OTTHUMG00000021222
OMIM ID 300798
String ID 9606.ENSP00000369274
PharmGKB ID PA33267
Target gene [PHKA2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6005627 chrX 47 19 16 82 View
6009388 chrX 25 12 37 View
6016240 chrX 12 12 View
6020680 chrX 6 6 View
6020682 chrX 6 6 View
6020691 chrX 6 6 View
6033411 chrX 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PHKA2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PHKA2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PHKA2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PHKA2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PHKA2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PHKA2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).